Zusammenfassung
Anliegen Der Einsatz antidepressiver Kombinationsbehandlungen wurde bisher nur in wenigen
Studien untersucht.
Methode Die Verschreibungspraxis antidepressiver Kombinationstherapien wurde am LVR-Klinikum
Düsseldorf bei Patienten mit schwerer depressiver Episode (ICD-10 F32.2 und F33.2)
retrospektiv untersucht.
Ergebnis Von 1198 stationären und teilstationären Fällen erhielten 25,1 % eine Kombination
aus zwei oder mehr Antidepressiva.
Schlussfolgerung Kombinationstherapien werden häufig eingesetzt, was einem geringen Empfehlungsgrad
der Behandlungsleitlinie gegenübersteht.
Abstract
Objectives Polypharmacy in the treatment of severe psychiatric disorders may include promising
treatment options, yet may also be subject to additional side effects and interactions.
In patients with severe depression, the prevalence of antidepressive (AD) combination
treatment has not been thoroughly assessed yet.
Methods We assessed the prevalence of antidepressive combination treatment in a sample of
hospital patients at the LVR-Clinic in Düsseldorf, Germany in 2012.
Results 1.198 residential or semi-residential patients were diagnosed with severe depressive
episode and were treated with at least one antidepressant. 25.1 % of those received
a combination of at least two antidepressants. The most frequent combination approaches
were tri- and tetracyclic AD with selective serotonin reuptake inhibitors (SSRI) yet
various other combination approaches were observed.
Conclusions Combination treatment is a common strategy. Future trends could be monitored via
electronic prescription software, yet prospective confirmatory trials are needed to
assess the rationale of different combination treatment approaches.
Schlüsselwörter
Depression, Antidepressiva - Polypharmazie - Kombinationsbehandlung - Qualitätserfassung
Keywords
depression - antidepressives - polypharmacy - combination treatment - quality assessment
